CCM>Free Info >News Update>1st volume No.2>
Last Update: Dec 31, 2000
Pharmaceuticals & Intermediates
Sample of Market Analysis
I. Industrial Policy
 
Precise Management on Agrochemicals in 2001 (Last update: 12/18/2000)
Ministry of Agriculture put forwards the management precises for agrochemicals in 2001. According to this statement, the Ministry of Agriculture will focus on the following areas in the year 2001: 1) To reinforce the management on test method, test unit and test sample; 2) To reinforce modification on agrochemical industry structure. In 2001, China will eliminate the production of agrochemicals that have only four year of expiry, especially those agrochemicals with high poison; 3) To reinforce the approval system for the registration of agrochemicals. A new and revised regulation, the Requirement for Registration of Agrochemicals, will come into force in 2001. (Source: China Chemical Industry News)
 
China Limits Application of Highly Poisonous Agrochemicals (Last update: 11/05/2000)
At present, the annual application of agrochemicals in China is about 0.8-1.0 million MT. But the industrial structure of agrochemical is not reasonable. About 70% of them are pesticide. And about 70% of the pesticide is high poisonous ones, threatening the human life in potential. So the Ministry of Agriculture publishes a regulation to limit the application of agrochemicals. Some of regulation include: 1) Suspend the registration on the application of methyl parathion and parathion in trees. About 125 factories are listed and are requested to stop the production of methyl parathion and parathion. 2) Stop the registration of methaimidophos, methyl parathion, monocrotophos, phosphamidon. Those already registered will be gradually suspended. 3) For the registration of other kind of agrochemicals, government will gradually limit their application and even suspend their application in the near future. (Source: China Chemical Industry News)
 
II. News Collection
 
7-ADCA Project in NCPC (Last update: 12/21/2000)
The project of 7-ADCA by enzyme method in North China Pharmaceutical Corporation (NCPC) has passed the approved from authority. It is the first time for China to break through the industrial production technology of 7-ADCA, an intermediate for the production of cephalosporins. Now NCPC has set up a 225MT/year production line of 7ADCA in its subsidiary, Beida Company. (Source: China Medicine News)
 
Largest Production Base of Transfusion (Last update:12/20/2000)
Beijing Shuanghe Pharmaceutical Co. Ltd. decides to invest capital to Wuhan Binhu Shuanghe Pharmaceutical Co. Ltd, in order to build the largest production base of transfusion in Wuhan. In the coming years, these two companies will build jointly a new production line with 300 million vial per year. It is expected that the sales value of this project will reach to RMB500 million after the construction. Now the production of transfusion in Wuhan Binhu Shuanghe is 100 million vial per year. (Source: China TCM News)
 
High Purity Diketene (Last update: 12/11/2000)
Shandong Zibo Development Zone Medicine Chemical Factory has invested RMB10 million to improve the production line of 3,000MT/year diketene facility. The Zibo factory cooperates with some research units to improve the cracking technology during the production. Now they can produce high purity of diketene (97.5%). Diketene is an important intermediate for dyestuff, synthetic fiber, plasticizer, medicine, agrochemical and food additive. (Source: China Chemical Industry News)
 
Refined Imidazole Production Line in Shanghai (Last update: 12/10/2000)
The 3,000MT/year Refine Imidazole Production line in Shanghai Sanwei Fine Chemical Factory has been set up. The assay of imidazole is 99.5%. Imidazole is an intermediate to make pharmaceutical and agrochemical. In the past the high content imidazole (99.5%) is supplied exclusively by BASF. It is reported that the product quality is the same as that of BASF, after Shanghai Sanwei Fine Chemical Factory solves the difficulties in the production. Now Shanghai Sanwei also produce dimethyl imidazole, benzimidazole. (Source: Shanghai Chemical Industry)
 
Production Base of Tsinghua Purple Light Pharm (Last update: 12/04/2000)
A modern pharmaceutical production base of Tsinghua Purple Light Pharmaceutical Co. has been built in suburb of Beijing. This production site is also designed for tourism. The total investment for the base is RMB150 million, covering over 20 hectares. The first phase construction consists of 5 production lines and 17 workshops, producing a various medicines to cure prostatitis, tumor, diabetes, hypertension, etc. The second phase will be built at the beginning of next year. Another 12 production lines will be installed in the second phase, producing biological products. (Source: Medicine Economic News)
 
Central Government to Support Medicine Industry (Last update: Dec 2000)
State Economic & Trade Committee issued notice recently, regulating the development emphasize on medicine industry in China. In the future, the central government will focus on the industrialization of scientific research, supporting gradually the key projects and some state new products. At the moment the central government determine to emphasize on the following item: 1) Modernization of TCM; 2) Biopharmaceutical; 3) Semi-synthetic penicillins, cephalosporins and relative intermediates;, vitamins and relative key technology. The central government requires that every enterprise should spend 6% if the total sales value on the scientific research by year 2005. (Source: Domestic Medicine Information Collection)
 
Free of VAT Agrochemicals (Last update: Dec 2000)
Customs Administration released in November the list of agrochemicals that are free of import VAT. These agrochemicals include 15 kinds of raw materials and 56 kinds of finish products (Source: cnchemicals.com)
 
Anhui Huayuan Pharm Set up (Last update: 11/25/2000)
Anhui Huayuan Pharmaceutical Co. Ltd. was set up in November 2000. It is based on the former Anhui Fuyang Pharmaceutical Factory. Now Anhui Huayuan Pharm. becomes a subsidiary of Shanghai Huayuan Pharmaceutical Co. Ltd., which is one of the top ten pharmaceutical groups in China and listed on stock. The main products in Anhui Huayuan Pharm include citric acid (30,000MT/year, capacity next to CCBA) and Yingguang Brand transfusion (50 million vials per year). (Source: China Medicine News)
 
Another Two Biopharmaceutical Projects in Shenzhen Petrochemical (Last update: 11/25/2000)
Shenzhen Petrochemical Corp Spike Biopharmaceutical Co. Ltd. signed agreement with PLA Airforce General Hospital and Tianjin Red Sun Pharmaceutical Co. Ltd. to introduce the project of GM-CSF and low molecular heparin calcium, respectively. The total investment for the two projects is RMB12 million. Spike Biopharmaceutical Co.Ltd. expects to get the New Drug License for the two drugs in the second half 2001 and launch them into the market at the same time. (Source: China Chemical Industry News)
 
Northern China Pharm. Becomes a National High-Tech Production Base (Last update: 11/21/2000)
Northern China Pharmaceutical Group is honored as one of the 51 high-tech production bases in China. Two of their projects, long term research project on gene pharmaceutical and the project of semisynthetic antibiotics by biological technology, are listed as innovative projects by State Economic & Trade Committee. During the Seventh-Five-Year-Plan, Northern China carried out the research on penicillin acetylase by gene technology. In the Eight-Five-Year-Plan, Northern China carried out the research on recombined macrophage colony stimulating factor (GM-CSF). Now they are undergoing the research on recombined buminate and self immunity therapy drug, PX3. In the past few years, the product species in Northern China has changed in three side: 1)from sole antibiotics to semisynthetic drug, gene pharmaceutical and biological pharmaceutical; 2) from bulk pharmaceuticals to bulk and preparations; 3) from anti-effective drug relying to multiple products including vitamin, biological agrochemicals, biological animal remedy, gene pharmaceutical and nutrition. Now there are a few main subsidiaries in Northern China: Beida Company: focusing on semisynthetic antibiotics; Jintan Company: focusing on Biological pharmaceutical, gene pharmaceutical; Ainuo Company: focusing on biological agrochemicals, animal remedy, etc. (Source: China Medicine News)
 
Spectromycin Project in Lukang Undergoing (Last update: 11/20/2000)
Shandong Lukang Pharmaceutical Group is undergoing the technical improvement on spectromycin. The investment for this project is RMB70 million. Now the 42x8 cubic meters fermentation tanks have been installed. Other constructions are undergoing as schedule. (Source:Medicine Economic News)
 
1,000MT/year Penicillin Downstream Project in Lukang (Last update: 11/11/2000)
The 1,000MT/year penicillin downstream production line in Shandong Lukang Group has been finished recently. Now Lukang can produce such downstream products of penicillin as amoxicillin capsule (via 6APA) and cefalexin (via 7-ACA). (Source: China High-Tech Technology News)
 
Hangzhou Sino-American Huangdong Pharm. Use New Technology in Cyclosporin Production (Last update: 10/23/2000)
Hangzhou Sino-American Huadong Pharmaceutical Group has been associating with Shanghai Medicine Industry Research Institute to do research on improving the production technology of cyclosporin. After three years work, the fermentation yield and fermentation index (on 20MT fermentation tank) has increased 96.6% and 159%, respectively. The new technology has been practiced for 9 months and gained good profit. It is estimated that this technology can save RMB3 million per year for Hangzhou factory and increase the production value by RMB80 million. (Source: Medicine Economic News)
 
Bio-antibiotics Earns More than RMB10 million for Lukang (Last update: 10/10/2000)
The antibiotics for crops and animal have become competitive products in Lukang Pharmaceutical Co.Ltd. From the beginning 2000 the company, on one hand, improved and enlarged its old product line,and, on the other hand, adopted new technology.Till now the production value of the mentioned antibiotics is RMB41.97 million and the profit from it is RMB11.47 million.The marketing strategy plays an important role for Lukang.The company holds many forum and exhibition on bioantibiotics in Guangzhou ,Shanghai, and build close marketing relationship with big feed producers such as Dajiang Group, Hope Group and Zhengda Group. Now the important bioantibiotics in Lukang include salinomycin, tlosin, which share one third of the Chinese market. They begin to produce sulfate colimycin which has been ordered out for the whole year. (Source: China Medicine News)
 
Ubenimex in Kangyu Pharm. (Last update: 10/09/2000)
The technical improvement project on ubenimex with capacity of 800kg per year has been carried out by Zhejiang Hengdian Group Kangyu Pharmaceutical Co. Ltd. Ubenimex is the type II new drug in China with action on medullary cell leukaemia,lung cancer,and nasopharyngeal cancer. It has little side effect and is very safe. (Source: Medicines Economic News)
 
Semi-synthetic Antibiotics in Northern China Pharm (Last update: 10/09/2000)
A semi-synthetic antibiotics product line was set up in Northern China Pharmaceutical Group, jointly invested by a Japanese company. The total investment for this line is USD59.99 million. The key facilities are imported from overseas. So far the production capacity of semi-synthetic antibiotics in Northern China has been 1,200MT/year, the largest one in Asia. (Source: Medicines Economic News)
 
Sales Turnover of Gene Pharm will be RMB2.28 billions This Year (Last update: October 2000)
Information from Ministry of Science & Technology disclosed that the sales turnover of gene pharmaceutical in China will be about RMB2.28 billions this year. The gene pharmaceutical in China started from 1989. The first one is Interferon aIb. By end of 1998, there were total 15 gene pharmaceutical available in China. And there are over 30 manufacturers are engaging in the gene pharmaceutical production. (Source: International Trade News).
 
China Announced the 23 Agrochemicals that are Forbidden to Invest in China (Last update: October 2000)

There are over 2,000 manufacturers of agrochemicals in China. But a majority of them produce the "me-too" agrochemical. The construction of agrochemical plants are too much repeated. Some agrochemicals are highly hazardous, some are oversupplying or outdated.

China publishes the catalogue that forbid the investment in the following agrochemicals: omethoate, methamidophos, benzene hexachloride,dichloro diphenyl trichloroethane, monocrotophos, thimet,acetofenate,Suhua 203, bromomethane,lindane, dibromdchloropropane, chlordimeform, tetramine, monofluoroacetamine, heptachlor, polychlorinated biphenyl, sodium floroacetate, pentachlorophenyl, sodium pentachlorophenyl, nitrofen, paraquat.

 
An Advanced Production Line of Procaine Penicillin in China (Last update: October 2000)
The largest production line of procaine penicillin in China has passed the sanitation recently. This line is developed jointly by Tianjin University and Hebei Huari Pharmaceutical Co. Ltd. in 1996. The procaine penicillin from Hebei Huari is uniform in particle size (5-10um). The overall yield is 2% higher than other manufacturers in China. So far the production in Hebei Huari occupied about one third of the total production in China. About 90% of their procaine penicillin is exported to Japan, Korea, Europe, America, Africa and Middle East. It is reported that their product occupies about 80% of the Japanese market. (Source: China Chemical Industry News)
 
Biotechnology Island will float up in WuHan (Last update: Oct 2000)
Aiming at high-tech development, Wuhan government plans to allocate a special district, called Biological Island, where covering 1000Mu and involving in the research, production, sales of ecological agrochemical,ecological medicine and ecological herbal medicine.The island is designed to be 1,000Mu. It will takes 5 years and cost RMB200 million to finish this project. (Source: China Chemical Industry News)
 
High-Level Construction Project in Changchun (Last update Oct. 2000)
The most advanced domestic pharmaceutical plant--Jilin Dongsheng Pharm Co.Ltd., was set up in Changchun. All the construction of the plant is strictly under the standard of GMP and FDA. It only took one year to finish the construction. Jilin Dongsheng Pharmaceutical Co. Ltd. is invested by Changchun Hongda Industrial Group and Northeast Normal University. The products in this factory include bioproduct, immunity products, nutrition products, western pharmaceuticals and TCM. It is expected that the output from this plant will be RMB320 million two years later and RMB500 million five years later. (Source: Pharmaceutical Express of China )
 
Hengrui Pharm. Develops over 40 kinds of New Medicines (Last update: Oct 2000)
In the first half year 2000 the output from Jiangsu Hengrui Pharmaceutical Co. Ltd. has been RMB269 million and the profit before tax has been RMB67.87 million. So far Hengrui Pharm. has developed more than 40 kinds of new medicines, among which 7 are unique and 10 are strong items in China. (Source: Pharmaceutical Express of China )
 
A Big & Potential Market for 4-methylimidazol in China (Last update: Oct 2000)
4-Methylimidazol is an important intermediate for the production of many pharmaceuticals,agrochemicals,ethoxyline firming agents and metal anticorrosive agents. At present the capacity of 4-methylimidazol in China is 1,000MT/Year and the actual production is 700MT/year.The main manufacturer are Jinjiang Chemical Construction Factory,Jinjiang Synthetical Chemical Factory and Southwest Pharmaceutical Factory Chongqing.It is estimated that the demand for 4-methylimidazol is about 2,000MT/year. (Source: Pharmaceutical Express of China )
 
Ambroxol Hydrochloride Granule Launches into China (09/30/2000)
Recently,ambroxol hydrochloride(Chinese name,Baimushu),the first species of this kind in China, has launched on Chinese market by Aidefa Pharm Co Ltd ,a Shanghai based Chinese-French joint venture.It is a thawer of grume and used to cure respiration disease.(Source: China Medicine News)
 
Nanometer Medicine with Anti-infective affection (Last update: 09/29/2000)
Recently Chinese scientists have developed nanometer medicine. The commercial production of this medicine began in Anxin Nanometer Biological Technology Co. Ltd. It symbolizes that China has been in leading position in the world to utilize nanometer material in medicine production. The Chinese patent is endowed to this technology and the application for FDA certificate is undergoing. (Source: China Chemical Industry News)
 
Dextro-4-hydroxyphenoxy Propionate and Bichongqing (Pesticide) Passed Test (Last update: 09/25/2000)
Two agrochemicals,Dextro-4-hydroxyphenoxy propionate and Bichongqing (a kind of pesticide),developed by Jiangsu Chemical Pesticide Co. Ltd. and Jiangsu Pesticide Research Institute,have passed test approval from certain authority .These two chemicals are among the key projects of the Ninth-Five-Year-Plan. Dextro-4-hydroxyphenoxy propionate is the main component of a highly effective herbicide,and Bichongqing is a new generation of highly effective and low poisonous pesticide.According to an authorative report,these two products have the same quality as those from the foreign companies. (Source: China Chemical Industry News)
 
List of Hatching Base in "863" Plan(medicine,biotechnology and chemical engineering) (Last update: 09/09/2000)
Ministry of Science and Technology appointed, in January and June, respectively, 51 enterprises as hatching bases for "863" Plan. The enterprises concerning with medicine,biotechnology and chemical engineering are: Shenzhen Kexing Biological Products Co.Ltd; Shandong Tianda Biological Products Co.Ltd; Northern China Pharm Co.Ltd(Group); Beijing Zhengkai bioengineering Development Co.Ltd; Changzhou Pharmaceutical Inc; WeiHai Medical Macromolecule Co.Ltd and Shenzhen Haiwang Pharm Co.Ltd (Source: Pharmaceutical Express of China )
The Export of Agrochemicals went up in the First Half 2000 (Last update: Sept 2000)
According to the statistics from customs, China totally exported 71,165 tons of agrochemicals, 30.1% increment over the same period in the last year. Among the export quantity, herbicide,insecticide,germicide accounts to 45.5%, 39.3% and 15.2%, respectively. (Source: China Chemical Industry News)
 
Wuhan Biological Science & Technology Island Merged (Last update: Sept 2000)
Wuhan Yuanzhou Biological Engineering Co.Ltd. signed contract with Wuhan government to build a biological science & technology island in Silver & Gold Lake of West Lake District. The Island will occupy 160 hectares, with total 80,000 square meters of construction area. The island will be divided by four parts for research, biopharmaceutical, agriculture, office. It is expected that total construction of the island will takes 5 years. (Source: TCM Business News)
 
Biopharmaceutical Project 248 Activated in Beijing (Last update: Sept 2000)
Beijing government decides to build four production bases and eight high-tech industrial projects in the future, calling "248" project. Beijing Biopharmaceutical Production Base and Modern Pharmaceutical Biological Technology Industrial Project are listed among the "248" project. The Beijing Biopharmaceutical Production Base is consist of Beijing University Biochemical City, Zhongguanchun Life Science Garden, Yizhuang Medicine Valley, etc. The Modern Pharmaceutical Biological Technology Industrial Project focuses on the research on the blood substitute, gene engineering pharmaceutical, etc. (Source: TCM Business News)